SiBionics Amplifying its CGM solution with Nordics nRF54L15

GS3

With its rollout, SiBionic's new continuous glucose monitoring device – the GS3 with Nordic's nRF54L15 Bluetooth LE SoC – offers people more flexibility and actionable insights on their blood sugar levels

SiBionics, a Chinese MedTech firm based in Shenzhen (Guangdong province), specializes in the R&D and commercialization of advanced active implantable medical devices and imaging AI. With R&D facilities in both China and Los Angeles, SiBionics operates across several medical-based verticals that focus on chronic disease diagnosis and management.

“We continuously innovate and iterate our products through implantable medical hardware technology and artificial intelligence algorithms, dedicated to driving global innovation and the popularization of continuous biomarker monitoring products,” explains Wayne Zhang, SiBionic’s Supply Chain Director. 

Among these is Continuous Glucose Monitoring (CGM) – non-stop, real-time tracking of a person’s blood sugar levels through wearable, implantable devices. While marketed primarily to people afflicted with diabetes, other groups have also shown interest in these devices. 

As Zhang explains, “Its main end-users are diabetic patients. However, with the increasing global health awareness, many non-diabetic groups are also accepting and using this product. This includes individuals with prediabetes, individuals with weight management needs, health-conscious individuals who monitor their blood glucose levels, and sports enthusiasts who optimize their metabolism and athletic performance through continuous glucose monitoring. These non-diabetic groups are gradually becoming part of the product's user base in the future years.”

Meet the world’s thinnest CGM device

Last year, SiBionics displayed its newest CGM solution - the SIBIONIS GS3 CGM system, consisting of a physically applied sensor and companion app. This device uses Nordic’s nRF54L15 System-on-Chip (SoC)

At less than three millimeters thick, the GS3 is marketed as “the world’s thinnest” CGM, designed to be user-friendly, seamless, and for virtually anyone consistently monitoring glucose levels or afflicted with diabetes, including the elderly and children as young as three years old.  

Weighing less than two grams, the GS3 offers a 14-day wear-time with an 18-month shelf-life, as well as other notable features similar to its predecessor, the SIBIONIS GS1. This includes real-time glucose monitoring, Bluetooth connectivity, customizable alerts, water resistance, and actionable insights with medical-grade accuracy. Similarly, the GS1 also uses a Nordic component - the nRF52832 System-on-Chip.  

“The SIBIONIS GS1 CGM was approved by China's NMPA (National Medical Products Administration) in November 2021 and is currently the best-selling CGM brand in China,” says Zhang. “Additionally, this product received the CE-MDR certification in October 2023 and has now covered over 100 countries and regions worldwide, serving more than 3 million users globally, with an annual production of approximately 10 million sets. The SIBIONIS GS3 CGM was granted CE-MDR certification in March 2025 and is planned to start large-scale mass production in 2026”.

In need of an upgrade 

During the prototyping phase, a key challenge was the GS3’s initially limited non-volatile memory (NVM). In the case of the GS3, the integrated NVM is used to store glucose readings, calibration data, and customized settings even when it loses power or is turned off, guaranteeing seamless performance. Also, it preserves historical measurements and logs, firmware, and configuration data for accurately analyzing trends and ensuring safe restarts after updates or power cycles. 

As Zhang explains, “If the flash space of the Bluetooth Low Energy (LE) chip is too small, it will be unable to meet the requirements of the new product, unable to store more user data, and unable to upgrade the algorithm version through iteration”. 

While the logical approach to this would have been upgrading to a bigger NVM solution, that would have meant using a physically larger component.  

However, a larger component would need more space and use more power. Given the GS3’s small size, space constraints, and energy needs, that was not a viable option. 

So, to meet these specific needs, SiBionics needed a component that had enough NVM, was energy efficient, and small enough to fit inside the GS3’s tiny frame. 

Quote
We’ve been using Nordic since the beginning of the GS1…the Bluetooth performance has been stable and reliable for a long time. We will still consider using Nordic products in future projects.
Wayne Zhang, Supply Chain Director - SiBionics

Why Nordic: A big upgrade inside a small package 

To satisfy these performance demands, SiBionics chose to use the nRF54L15 Bluetooth LE SoC. 

As part of Nordic’s nRF54L Series – our ultra-low-power SoCs combining wireless connectivity with the functionality of a microcontroller unit (MCU) inside a compact package – the nRF54L15 SoC is designed for ultra-low-power IoT applications. It offers high efficiency, strong security, and flexible connectivity. This makes it ideal for both wearable and medical tech devices. 

For the GS3, the SoC is packed inside a Chip-Scale Package (CSP). This offers an ultra compact packaging option (2.4mm x 2.2mm), making it ideal for space-constrained products – ensuring maximum performance inside a minimum space. 

Also, the nRF54L15 offers more NVM for the GS3 without taking up more space. This provides the sensor with a larger user-data storage option. Combined with the standard features of the nRF54L Series, including lower power consumption and enhanced overall performance, this makes the nRF54L15 a robust, reliable component. 

“The nRF54L15 has sufficient flash and RAM resources to meet the increasing requirements of the product,” explains Zhang. He adds, “The CSP size is applicable, and the power consumption is excellent”. 

Furthermore, the nRF54L15 delivers more compared to its predecessor, the nRF52832. It offers a faster processor, more memory, and supports more advanced protocols like Bluetooth LE, Thread, Matter, and Zigbee. 

Moving forward with more collaborations

Thanks to the nRF54L15, SiBionics has developed a next-gen CGM that is smaller, more comfortable, and capable of more than its predecessor and most models. And with the potential success of the GS3, SiBionics is very optimistic about future collaborations with Nordic Semiconductor. 

“We have long admired the precision and sophistication of SiBionics’ products, and our collaboration over the years has created meaningful value for both our companies,” says Geir Langeland, EVP, Sales and Marketing at Nordic Semiconductor. “We especially appreciate their recognition of the performance and efficiency the nRF54L15 brings to their cutting-edge technology. We look forward to continuing this strong and mutually beneficial partnership.”

“SiBionics always recognized Nordic as a core strategic partner,” says Zhang. “We will still consider using Nordic products in future projects”.